TCT-843 Association of Dual Antiplatelet Therapy and PAI-1 in Coronary Artery Disease

Dual antiplatelet therapy for secondary prevention of coronary artery disease

Dual antiplatelet therapy (DAPT) combining aspirin and a P2Y12 receptor inhibitor has been consistently shown to reduce recurrent major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) compared with aspirin monotherapy, but at the expense of an increased risk of maj...

Is Aspirin Still the Cornerstone of Antiplatelet Therapy in Patients With Coronary Artery Disease? An Historical and Practical Narrative Review

Aspirin is an irreversible and non-selective inhibitor of cyclo-oxygenase. It represents the cornerstone of antiplatelet therapy and is used in secondary prevention of cardiovascular disease. Disagreement over the optimal maintenance dosage still exists; in America and Europe the most used doses of aspirin are 81 mg and 100 mg daily, respectively. There is also debate on the formulation and rou...

Association of Hyperhomocysteinemia with Coronary Artery Disease in Southern Iran

Association of vitamin D deficiency and premature coronary artery disease

Background: Evidence suggests hypovitaminosis D is associated with increased risk of coronary artery disease (CAD) and its extent and related risk factors. However, some investigations have produced contrary results. Therefore, we aimed to evaluate the association between serum vitamin D levels and the severity of premature coronary artery involvement. Methods: This randomized prospective, cas...

Association of hyperhomocysteinemia with coronary artery disease in southern Iran

Dear Editor, In response to the criticisms regarding the article entitled; “association of hyperhomocysteinemia with coronary artery disease in Southern Iran”, published in Iran J Med Sci,1 we still believe the methodology used in this study was a case control design as the cases where chosen on the basis of outcome (coronary artery disease) and the controls were individuals without the disease...